Tachyphylaxis and Tolerance: Biomathematics of Rate Sensitivity biomathematicsblog TOLERANCE & TACHYPHYLAXIS Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Effect of ascorbate on tachyphylaxis of 30 nM isoproterenol (IP) Download Scientific Diagram